ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dock9

Full Name:

dedicator of cytokinesis 9

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 E5|14 67.0 cM

Physical Location:

121941260-122097638 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23348 Symbol (Name): DOCK9 (dedicator of cytokinesis 9)

Ortholog Status:

The human GeneID 23348 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D14Wsu89e
Original ID2:		AW125299

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001081039.1	NP_001074508.1	NC_000080.5 range: 121941260..122097638, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IDA (15710388)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0017048	Rho GTPase binding	Molecular Function	IPI (15710388)
GO:0051020	GTPase binding	Molecular Function	IEA