ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TXNIP

Full Name:

thioredoxin interacting protein

Alias:

EST01027|HHCPA78|THIF|VDUP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q21.1

Physical Location:

144149938-144153881 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 56338 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		S73591
Fold Change:		-1.4, -1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006472.3	NP_006463.3	NC_000001.9 range: 144149938..144153881

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (14632196)
GO:0005515	protein binding	Molecular Function	IPI (14632196)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0030216	keratinocyte differentiation	Biological Process	IDA (14632196)