ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Txnip

Full Name:

thioredoxin interacting protein

Alias:

1200008J08Rik|AA682105|Hyplip1|THIF|VDUP1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 47.1 cM

Physical Location:

96361879-96365788 on NC_000069.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10628 Symbol (Name): TXNIP (thioredoxin interacting protein)

Ortholog Status:

The human GeneID 10628 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI839138
Fold Change:		2.3, 1.7, 2.5, 1.2
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (10843682)
GO:0004857	enzyme inhibitor activity	Molecular Function	IDA (10843682)
GO:0005515	protein binding	Molecular Function	IPI (10843682)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006979	response to oxidative stress	Biological Process	IDA (10843682)
GO:0007049	cell cycle	Biological Process	IEA