ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POSTN

Full Name:

periostin, osteoblast specific factor

Alias:

MGC119510|MGC119511|OSF-2|PDLPOSTN|PN|RP11-412K4.1|periostin

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q13.3

Physical Location:

37034778-37070873 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 50706 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S171

32151912

Region:		32151912-40979230
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006475.1	NP_006466.1	NC_000013.9 range: 37034778..37070873, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	ISS
GO:0001501	skeletal development	Biological Process	TAS (8363580)
GO:0007155	cell adhesion	Biological Process	IDA (12235007)