ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KHDRBS1

Full Name:

KH domain containing, RNA binding, signal transduction associated 1

Alias:

FLJ34027|Sam68|p62

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p32

Physical Location:

32252077-32282058 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.445893
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006559.1	NP_006550.1	NC_000001.9 range: 32252077..32282058

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (1374686)
GO:0016020	membrane	Cellular Component	IDA (1374686)
GO:0003677	DNA binding	Molecular Function	TAS (1374686)
GO:0003723	RNA binding	Molecular Function	IDA (1374686)
GO:0005070	SH3/SH2 adaptor activity	Molecular Function	IPI (9045636)
GO:0005515	protein binding	Molecular Function	IPI (9045636\|11278465\|11585385\|16341228)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	ISS
GO:0008283	cell proliferation	Biological Process	TAS (9013542)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IDA (9045636)
GO:0007050	cell cycle arrest	Biological Process	TAS (9013542)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	TAS (1374686)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0046831	regulation of RNA export from nucleus	Biological Process	ISS