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Gene Information
Gene ID:10657
Full Name:KH domain containing, RNA binding, signal transduction associated 1
Organism:Homo sapiens (Human)
Genetic Location:1p32
Physical Location:32252077-32282058 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.445893
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006559.1NP_006550.1NC_000001.9 range: 32252077..32282058
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (1374686)
GO:0016020membraneCellular ComponentIDA (1374686)
GO:0003677DNA bindingMolecular FunctionTAS (1374686)
GO:0003723RNA bindingMolecular FunctionIDA (1374686)
GO:0005070SH3/SH2 adaptor activityMolecular FunctionIPI (9045636)
GO:0005515protein bindingMolecular FunctionIPI (9045636|11278465|11585385|16341228)
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0000086G2/M transition of mitotic cell cycleBiological ProcessISS
GO:0008283cell proliferationBiological ProcessTAS (9013542)
GO:0007166cell surface receptor linked signal transductionBiological ProcessIDA (9045636)
GO:0007050cell cycle arrestBiological ProcessTAS (9013542)
GO:0007049cell cycleBiological ProcessIEA
GO:0006397mRNA processingBiological ProcessTAS (1374686)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0046831regulation of RNA export from nucleusBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:10657
HuGE Navigator:10657