ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Otub1

Full Name:

OTU domain, ubiquitin aldehyde binding 1

Alias:

AI850305

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 A

Physical Location:

7272695-7280773 on NC_000085.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55611 Symbol (Name): OTUB1 (OTU domain, ubiquitin aldehyde binding 1)

Ortholog Status:

The human GeneID 55611 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Otub1
Original ID2:		AI838318

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134150.2	NP_598911.1	NC_000085.5 range: 7272695..7280773, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA