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Gene Information
Gene ID:107260
Full Name:OTU domain, ubiquitin aldehyde binding 1
Organism:Mus musculus (Mouse)
Genetic Location:19 A
Physical Location:7272695-7280773 on NC_000085.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 55611    Symbol (Name): OTUB1 (OTU domain, ubiquitin aldehyde binding 1)
Ortholog Status:The human GeneID 55611 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Otub1
Original ID2:AI838318
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134150.2NP_598911.1NC_000085.5 range: 7272695..7280773, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008233peptidase activityMolecular FunctionIEA
GO:0008234cysteine-type peptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006955immune responseBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:107260