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Gene Information
Gene ID:108655
Full Name:forkhead box P1
Organism:Mus musculus (Mouse)
Genetic Location:6 E1
Physical Location:98880083-99113011 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 27086    Symbol (Name): FOXP1 (forkhead box P1)
Ortholog Status:The human GeneID 27086 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Foxp1
Original ID2:AA833293
Gene Information
Original ID1:Foxp1
Original ID2:AW122985
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053202.1NP_444432.1NC_000072.5 range: 98880083..99113011, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (14701752)
GO:0005634nucleusCellular ComponentIDA (16819554)
GO:0005622intracellularCellular ComponentIEA
GO:0016566specific transcriptional repressor activityMolecular FunctionIDA (17428829)
GO:0042803protein homodimerization activityMolecular FunctionIPI (14701752)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (14701752)
GO:0016564transcription repressor activityMolecular FunctionIDA (11358962|14701752)
GO:0046982protein heterodimerization activityMolecular FunctionIPI (14701752)
GO:0003677DNA bindingMolecular FunctionIDA (14701752)
GO:0003700transcription factor activityMolecular FunctionIDA (17428829)
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingMolecular FunctionIDA (16819554)
GO:0033152immunoglobulin V(D)J recombinationBiological ProcessIMP (16819554)
GO:0030324lung developmentBiological ProcessIGI (17428829)
GO:0050679positive regulation of epithelial cell proliferationBiological ProcessIGI (17428829)
GO:0048745smooth muscle developmentBiological ProcessIGI (17428829)
GO:0016481negative regulation of transcriptionBiological ProcessIDA (11358962)
GO:0009790embryonic developmentBiological ProcessIMP (16819554)
GO:0002053positive regulation of mesenchymal cell proliferationBiological ProcessIGI (17428829)
GO:0002329pre-B cell differentiationBiological ProcessIMP (16819554)
GO:0002639positive regulation of immunoglobulin productionBiological ProcessIMP (16819554)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007507heart developmentBiological ProcessIMP (15342473)
GO:0007519skeletal muscle developmentBiological ProcessIGI (17428829)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (14701752|17428829)
GO:0009790embryonic developmentBiological ProcessIGI (17428829)
GO:0055007cardiac muscle cell differentiationBiological ProcessIMP (15342473)
Other Database Cross Links
NCBI Entrez Gene:108655