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Gene Information
Gene ID:10888
Symbol:GPR83
Full Name:G protein-coupled receptor 83
Alias:GIR|GPR72
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q21
Physical Location:93750130-93774065 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.272385
Note:"Class I, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016540.2NP_057624.2NC_000011.8 range: 93750130..93774065, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0004983neuropeptide Y receptor activityMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:10888
HGNC:4523
Ensembl:ENSG00000123901
MIM:605569
HPRD:16125
HuGE Navigator:10888
dbSNP:GPR83
GeneCard:GPR83
AceView:GPR83