ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

YWHAQ

Full Name:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Alias:

14-3-3|1C5|HS1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2p25.1

Physical Location:

9641556-9688556 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22630 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X56468
Fold Change:		1.7, 1.4
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006826.2	NP_006817.1	NC_000002.10 range: 9641556..9688556, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0008426	protein kinase C inhibitor activity	Molecular Function	NR
GO:0019904	protein domain specific binding	Molecular Function	IEA
GO:0006887	exocytosis	Biological Process	NR
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (15163635)