ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ywhaq

Full Name:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Alias:

14-3-3theta|2700028P07Rik|AA409740|AU021156|MGC118161|R74690|RP23-402H11.1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 A1.3

Physical Location:

21396189-21423296 on NC_000078.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10971 Symbol (Name): YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide)

Ortholog Status:

The human GeneID 10971 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U56243
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011739.3	NP_035869.1	NC_000078.5 range: 21396189..21423296, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0019904	protein domain specific binding	Molecular Function	IDA (12446771)
GO:0006605	protein targeting	Biological Process	IDA (12446771)
GO:0007165	signal transduction	Biological Process	TAS (9211421)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IPI (9211421)