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Gene Information
Gene ID:22630
Symbol:Ywhaq
Full Name:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Alias:14-3-3theta|2700028P07Rik|AA409740|AU021156|MGC118161|R74690|RP23-402H11.1
Organism:Mus musculus (Mouse)
Chromosome:12
Genetic Location:12 A1.3
Physical Location:21396189-21423296 on NC_000078.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10971    Symbol (Name): YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide)
Ortholog Status:The human GeneID 10971 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U56243
Note:Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains
Dataset Information
Name:15282116
Method:Microarray
Tissue:Striata
Phenotype:Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011739.3NP_035869.1NC_000078.5 range: 21396189..21423296, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0005737cytoplasmCellular ComponentIEA
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0019904protein domain specific bindingMolecular FunctionIDA (12446771)
GO:0006605protein targetingBiological ProcessIDA (12446771)
GO:0007165signal transductionBiological ProcessTAS (9211421)
GO:0007264small GTPase mediated signal transductionBiological ProcessIPI (9211421)
Other Database Cross Links
NCBI Entrez Gene:22630
MGI:
Ensembl:ENSMUSG00000066598
dbSNP:Ywhaq
AceView:Ywhaq