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Gene Information
Gene ID:109711
Full Name:actinin, alpha 1
Organism:Mus musculus (Mouse)
Genetic Location:12 C3|12 35.0 cM
Physical Location:81268533-81361302 on NC_000078.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 87    Symbol (Name): ACTN1 (actinin, alpha 1)
Ortholog Status:The human GeneID 87 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Actn1
Original ID2:AI195392
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:Actn1
Fold Change:0.52
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134156.1NP_598917.1NC_000078.5 range: 81268533..81361302, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001725stress fiberCellular ComponentTAS (15841212)
GO:0032127dense core granule membraneCellular ComponentTAS (16043482)
GO:0030863cortical cytoskeletonCellular ComponentTAS (15841212)
GO:0030141secretory granuleCellular ComponentNAS (16043482)
GO:0030018Z discCellular ComponentIDA (15665106)
GO:0015629actin cytoskeletonCellular ComponentISO
GO:0005925focal adhesionCellular ComponentTAS (15841212)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (12223541|16043482)
GO:0005509calcium ion bindingMolecular FunctionRCA (12466851)
GO:0051015actin filament bindingMolecular FunctionIDA (15465019)
GO:0003779actin bindingMolecular FunctionISO
GO:0042803protein homodimerization activityMolecular FunctionTAS (15841212)
GO:0008150biological_processBiological ProcessND
GO:0030865cortical cytoskeleton organization and biogenesisBiological ProcessTAS (15841212)
GO:0051017actin filament bundle formationBiological ProcessIDA (16043482)
Other Database Cross Links
NCBI Entrez Gene:109711