ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Qdpr

Full Name:

quinoid dihydropteridine reductase

Alias:

2610008L04Rik|D5Ertd371e|Dhpr|PKU2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 B3|5 30.0 cM

Physical Location:

45825293-45841395 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5860 Symbol (Name): QDPR (quinoid dihydropteridine reductase)

Ortholog Status:

The human GeneID 5860 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Qdpr
Original ID2:		AI845337

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024236.1	NP_077198.1	NC_000071.5 range: 45825293..45841395, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004155	6,7-dihydropteridine reductase activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	RCA (16141072)
GO:0006729	tetrahydrobiopterin biosynthetic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	RCA (16141072)