| Gene Information |
| Gene ID: | | 110454 |
| Symbol: | | Ly6a |
| Full Name: | | lymphocyte antigen 6 complex, locus A |
| Alias: | | Ly-6A.2|Ly-6A/E|Ly-6E.1|Sca-1|Sca1|TAP |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 15 |
| Genetic Location: | | 15 D3|15 42.7 cM |
| Physical Location: | | 74825306-74828317 on NC_000081.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | X04653 | | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| | Dataset Information | | Name: | | 15282116 | | Method: | | Microarray | | Tissue: | | Striata | | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Lore5 | Alcohol-induced Loss of Righting Reflex | 15 | | 18.8-61.7 (cM) | 4 | | Significant | PARC | | Aaq1/Etacc | Alcohol Acceptance | 15 | 30 | 15-48 (cM) | 3.8 | | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IDA (11146504) | |
| GO:0009897 | external side of plasma membrane | Cellular Component | IDA (12714519|12935903) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0031225 | anchored to membrane | Cellular Component | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 110454 |
| MGI: | |
| Ensembl: | | ENSMUSG00000075602 |
| dbSNP: | | Ly6a |
| AceView: | | Ly6a |
