Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:110532
Full Name:adenosine deaminase, RNA-specific, B1
Organism:Mus musculus (Mouse)
Genetic Location:10 41.4 cM
Physical Location:76753477-76881017 on NC_000076.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 104    Symbol (Name): ADARB1 (adenosine deaminase, RNA-specific, B1 (RED1 homolog rat))
Ortholog Status:The human GeneID 104 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Adarb1
Original ID2:AV345565
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001024837.2NP_001020008.1NC_000076.5 range: 76753477..76881017, complement
NM_001024838.1NP_001020009.1NC_000076.5 range: 76753477..76881017, complement
NM_001024839.1NP_001020010.1NC_000076.5 range: 76753477..76881017, complement
NM_001024840.1NP_001020011.1NC_000076.5 range: 76753477..76881017, complement
NM_130895.3NP_570965.2NC_000076.5 range: 76753477..76881017, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS (12459255)
GO:0005622intracellularCellular ComponentIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0004000adenosine deaminase activityMolecular FunctionIEA
GO:0003726double-stranded RNA adenosine deaminase activityMolecular FunctionISS (12459255)
GO:0003725double-stranded RNA bindingMolecular FunctionISS (12459255)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006396RNA processingBiological ProcessIEA
GO:0006397mRNA processingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:110532