ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adarb1

Full Name:

adenosine deaminase, RNA-specific, B1

Alias:

1700057H01Rik|AW124433|AW558573|Adar2|BB220382|D10Bwg0447e|Red1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 41.4 cM

Physical Location:

76753477-76881017 on NC_000076.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 104 Symbol (Name): ADARB1 (adenosine deaminase, RNA-specific, B1 (RED1 homolog rat))

Ortholog Status:

The human GeneID 104 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adarb1
Original ID2:		AV345565

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS (12459255)
GO:0005622	intracellular	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0004000	adenosine deaminase activity	Molecular Function	IEA
GO:0003726	double-stranded RNA adenosine deaminase activity	Molecular Function	ISS (12459255)
GO:0003725	double-stranded RNA binding	Molecular Function	ISS (12459255)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006396	RNA processing	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	IEA