ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aldh7a1

Full Name:

aldehyde dehydrogenase family 7, member A1

Alias:

Atq1|D18Wsu181e

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 D3|18 29.0 cM

Physical Location:

56685389-56732525 on NC_000084.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 501 Symbol (Name): ALDH7A1 (aldehyde dehydrogenase 7 family, member A1)

Ortholog Status:

The human GeneID 501 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI835461
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_138600.4	NP_613066.2	NC_000084.5 range: 56685389..56732525, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0007605	sensory perception of sound	Biological Process	RCA (12466851)
GO:0008152	metabolic process	Biological Process	RCA (12466851)