ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CHD4

Full Name:

chromodomain helicase DNA binding protein 4

Alias:

DKFZp686E06161|Mi-2b|Mi2-BETA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13

Physical Location:

6549508-6586811 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 40170 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001273.2	NP_001264.2	NC_000012.10 range: 6549508..6586811, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000785	chromatin	Cellular Component	IEA
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	TAS (7560064)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15231747\|17314511)
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	TAS (9326634)
GO:0003682	chromatin binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	TAS (9326634)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006333	chromatin assembly or disassembly	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (9326634)
GO:0016568	chromatin modification	Biological Process	IEA