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Gene Information
Gene ID:1108
Full Name:chromodomain helicase DNA binding protein 4
Organism:Homo sapiens (Human)
Genetic Location:12p13
Physical Location:6549508-6586811 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has Fly: 40170 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001273.2NP_001264.2NC_000012.10 range: 6549508..6586811, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0000785chromatinCellular ComponentIEA
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionTAS (7560064)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15231747|17314511)
GO:0004003ATP-dependent DNA helicase activityMolecular FunctionTAS (9326634)
GO:0003682chromatin bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionTAS (9326634)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006333chromatin assembly or disassemblyBiological ProcessIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (9326634)
GO:0016568chromatin modificationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1108
HuGE Navigator:1108