ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mi-2

Alias:

0006/06|0854/01|CG8103|Dm-Mi-2|MI2|Mi 2|Pha|dMI-2|dMi|hip76|l(3)01058|l(3)A154.3M3|l(3)S000606|l(3)S085401|l(3)j3D4

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

76D3-76D4

Physical Location:

19875144-19903308 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1108 Symbol (Name): CHD4 (chromodomain helicase DNA binding protein 4)

Ortholog Status:

The human GeneID 1108 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mi-2
P Value:		3.20E-02
Note:		Transient down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IEA
GO:0016581	NuRD complex	Cellular Component	TAS (11743021)
GO:0016581	NuRD complex	Cellular Component	ISS (10904264)
GO:0005700	polytene chromosome	Cellular Component	IDA (11743021)
GO:0005634	nucleus	Cellular Component	NAS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	NAS
GO:0016887	ATPase activity	Molecular Function	IDA (12006495\|16223721)
GO:0003677	DNA binding	Molecular Function	IDA (12006495)
GO:0003678	DNA helicase activity	Molecular Function	ISS
GO:0016564	transcription repressor activity	Molecular Function	IGI
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0003682	chromatin binding	Molecular Function	ISS
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	ISS (10471706)
GO:0004386	helicase activity	Molecular Function	ISS (10908586)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0031491	nucleosome binding	Molecular Function	IDA (16223721)
GO:0042766	nucleosome mobilization	Biological Process	IDA (12006495\|16223721)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0007517	muscle development	Biological Process	IMP (16547170)
GO:0006333	chromatin assembly or disassembly	Biological Process	ISS
GO:0048813	dendrite morphogenesis	Biological Process	IMP (16547170)