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Gene Information
Gene ID:40170
Alias:0006/06|0854/01|CG8103|Dm-Mi-2|MI2|Mi 2|Pha|dMI-2|dMi|hip76|l(3)01058|l(3)A154.3M3|l(3)S000606|l(3)S085401|l(3)j3D4
Organism:Drosophila melanogaster (Fly)
Genetic Location:76D3-76D4
Physical Location:19875144-19903308 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1108    Symbol (Name): CHD4 (chromodomain helicase DNA binding protein 4)
Ortholog Status:The human GeneID 1108 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mi-2
P Value:3.20E-02
Note:Transient down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014591.1NP_001014591.1NT_037436.3 range: 19875144..19903308, complement
NM_140897.2NP_649154.2NT_037436.3 range: 19875144..19903308, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000785chromatinCellular ComponentIEA
GO:0016581NuRD complexCellular ComponentTAS (11743021)
GO:0016581NuRD complexCellular ComponentISS (10904264)
GO:0005700polytene chromosomeCellular ComponentIDA (11743021)
GO:0005634nucleusCellular ComponentNAS
GO:0005634nucleusCellular ComponentISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0016887ATPase activityMolecular FunctionNAS
GO:0016887ATPase activityMolecular FunctionIDA (12006495|16223721)
GO:0003677DNA bindingMolecular FunctionIDA (12006495)
GO:0003678DNA helicase activityMolecular FunctionISS
GO:0016564transcription repressor activityMolecular FunctionIGI
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008026ATP-dependent helicase activityMolecular FunctionIEA
GO:0003682chromatin bindingMolecular FunctionISS
GO:0004003ATP-dependent DNA helicase activityMolecular FunctionISS (10471706)
GO:0004386helicase activityMolecular FunctionISS (10908586)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0031491nucleosome bindingMolecular FunctionIDA (16223721)
GO:0042766nucleosome mobilizationBiological ProcessIDA (12006495|16223721)
GO:0045449regulation of transcriptionBiological ProcessIEA
GO:0007517muscle developmentBiological ProcessIMP (16547170)
GO:0006333chromatin assembly or disassemblyBiological ProcessISS
GO:0048813dendrite morphogenesisBiological ProcessIMP (16547170)
Other Database Cross Links
NCBI Entrez Gene:40170