ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FAF1

Full Name:

Fas (TNFRSF6) associated factor 1

Alias:

CGI-03|FLJ37524|HFAF1s|hFAF1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p33

Physical Location:

50679522-51198523 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 36769 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.530402
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007051.2	NP_008982.1	NC_000001.9 range: 50679522..51198523, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15596450)
GO:0005829	cytosol	Cellular Component	IDA (15596450)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (11713579)
GO:0031265	CD95 death-inducing signaling complex	Cellular Component	NAS (12702723)
GO:0031072	heat shock protein binding	Molecular Function	IDA (15596450)
GO:0030191	Hsp70/Hsc70 protein inhibitor activity	Molecular Function	IDA (15596450)
GO:0019901	protein kinase binding	Molecular Function	IDA (11713579)
GO:0008605	protein kinase CK2 regulator activity	Molecular Function	NAS (11713579)
GO:0051059	NF-kappaB binding	Molecular Function	IPI (14600157)
GO:0008219	cell death	Biological Process	IMP (15743842)
GO:0031334	positive regulation of protein complex assembly	Biological Process	IMP (15688372)
GO:0042176	regulation of protein catabolic process	Biological Process	IMP (15743842)
GO:0043065	positive regulation of apoptosis	Biological Process	NAS (10462485)
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	NAS (15743842)
GO:0007253	cytoplasmic sequestering of NF-kappaB	Biological Process	IMP (14600157)