| Gene Information | | Original ID1: | | X04120 | | Fold Change: | | NC, NC, 1.5, 1.6 | | Note: | | 4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2 |
| | Dataset Information | | Name: | | 15002731 | | Method: | | Microarray | | Tissue: | | Whole brain | | Phenotype: | | Acute ethanol response | | Publication: | | Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed | | Summary: | | We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain. |
| | Gene Information | | Original ID1: | | --- | | Original ID2: | | X04120 |
| | Dataset Information | | Name: | | 15745951 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, prefrontal cortex, and ventral tegmental area | | Phenotype: | | Acute ethanol response | | Publication: | | Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed | | Summary: | | The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area. |
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