ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Abl1

Full Name:

c-abl oncogene 1, receptor tyrosine kinase

Alias:

AI325092|Abl|E430008G22Rik|MGC117749|c-Abl

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 B|2 21.0 cM

Physical Location:

31615501-31659746 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 25 Symbol (Name): ABL1 (c-abl oncogene 1, receptor tyrosine kinase)

Ortholog Status:

The human GeneID 25 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Abl1
Fold Change:		1.59
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009594.3	NP_033724.2	NC_000068.6 range: 31615501..31659746

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	ISS (17101133)
GO:0005730	nucleolus	Cellular Component	ISO
GO:0005634	nucleus	Cellular Component	IDA (9636171)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (9636171)
GO:0016301	kinase activity	Molecular Function	IDA (12379650)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IDA (9109492)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (9109492)
GO:0000287	magnesium ion binding	Molecular Function	IDA (9109492)
GO:0004672	protein kinase activity	Molecular Function	IDA (12672821)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15148308\|17254966)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA (9109492)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IDA (11279004)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0051726	regulation of cell cycle	Biological Process	IDA (11809706)