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Gene Information
Gene ID:11350
Full Name:c-abl oncogene 1, receptor tyrosine kinase
Organism:Mus musculus (Mouse)
Genetic Location:2 B|2 21.0 cM
Physical Location:31615501-31659746 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:GeneID: 25    Symbol (Name): ABL1 (c-abl oncogene 1, receptor tyrosine kinase)
Ortholog Status:The human GeneID 25 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Abl1
Fold Change:1.59
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcp1Alcohol Preference Drinking22819-35 (cM)5.3 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009594.3NP_033724.2NC_000068.6 range: 31615501..31659746
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentISS (17101133)
GO:0005730nucleolusCellular ComponentISO
GO:0005634nucleusCellular ComponentIDA (9636171)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (9636171)
GO:0016301kinase activityMolecular FunctionIDA (12379650)
GO:0016740transferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0030145manganese ion bindingMolecular FunctionIDA (9109492)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIDA (9109492)
GO:0000287magnesium ion bindingMolecular FunctionIDA (9109492)
GO:0004672protein kinase activityMolecular FunctionIDA (12672821)
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0004715non-membrane spanning protein tyrosine kinase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15148308|17254966)
GO:0007155cell adhesionBiological ProcessIEA
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessIDA (9109492)
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessIDA (11279004)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0051726regulation of cell cycleBiological ProcessIDA (11809706)
Other Database Cross Links
NCBI Entrez Gene:11350