ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CHRNA5

Full Name:

cholinergic receptor, nicotinic, alpha 5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q24

Physical Location:

76644960-76673514 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 110835 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CHRNA5

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
CHRNA5	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000745.2	NP_000736.2	NC_000015.8 range: 76644960..76673514

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	Cellular Component	IC (1542648)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0015464	acetylcholine receptor activity	Molecular Function	IDA (1542648)
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	NAS (1542648)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0007268	synaptic transmission	Biological Process	TAS (9009220)
GO:0006811	ion transport	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	NAS (9009220)