ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Acaa1a

Full Name:

acetyl-Coenzyme A acyltransferase 1A

Alias:

Acaa|Acaa1|D9Ertd25e|MGC7090|PTL

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F4|9 71.0 cM

Physical Location:

119250411-119259412 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 30 Symbol (Name): ACAA1 (acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase))

Ortholog Status:

The human GeneID 30 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI841705
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_130864.3	NP_570934.1	NC_000075.5 range: 119250411..119259412

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005777	peroxisome	Cellular Component	TAS (11461119)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0003985	acetyl-CoA C-acetyltransferase activity	Molecular Function	TAS (11461119)
GO:0003988	acetyl-CoA C-acyltransferase activity	Molecular Function	RCA (12466851)
GO:0008415	acyltransferase activity	Molecular Function	RCA (12466851)
GO:0016740	transferase activity	Molecular Function	RCA (12466851)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006631	fatty acid metabolic process	Biological Process	TAS (11461119)
GO:0008152	metabolic process	Biological Process	IEA