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Gene Information
Gene ID:1139
Full Name:cholinergic receptor, nicotinic, alpha 7
Organism:Homo sapiens (Human)
Genetic Location:15q14
Physical Location:30110017-30248540 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CHRNA7
Original ID2:X70297
Dataset Information
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:CHRNA7
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000746.3NP_000737.1NC_000015.8 range: 30110017..30248540
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0005892nicotinic acetylcholine-gated receptor-channel complexCellular ComponentIDA (8906617)
GO:0005886plasma membraneCellular ComponentIDA (16280133)
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentNAS (8145738|8906617)
GO:0015643toxin bindingMolecular FunctionIDA (12508119)
GO:0042803protein homodimerization activityMolecular FunctionIDA (8145738)
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0015464acetylcholine receptor activityMolecular FunctionIDA (8906617)
GO:0017081chloride channel regulator activityMolecular FunctionIDA (8145738)
GO:0001540beta-amyloid bindingMolecular FunctionIPI (10681545)
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityMolecular FunctionIDA (8145738|8906617)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0032720negative regulation of tumor necrosis factor productionBiological ProcessIMP (12508119)
GO:0035094response to nicotineBiological ProcessIDA (8145738|12189247)
GO:0050890cognitionBiological ProcessIMP (16754836)
GO:0050728negative regulation of inflammatory responseBiological ProcessIDA (12508119)
GO:0045766positive regulation of angiogenesisBiological ProcessIMP (12189247|16280133)
GO:0000187activation of MAPK activityBiological ProcessIDA (10771023)
GO:0001666response to hypoxiaBiological ProcessIDA (12189247)
GO:0006811ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessNAS (8906617)
GO:0006816calcium ion transportBiological ProcessIDA (8145738)
GO:0006816calcium ion transportBiological ProcessIMP (10771023)
GO:0006874cellular calcium ion homeostasisBiological ProcessIMP (16280133)
GO:0007165signal transductionBiological ProcessIDA (8906617)
GO:0007613memoryBiological ProcessNAS (10681545)
GO:0008284positive regulation of cell proliferationBiological ProcessIMP (16280133|17498763)
GO:0050890cognitionBiological ProcessNAS (10681545)
Other Database Cross Links
NCBI Entrez Gene:1139
HuGE Navigator:1139