Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:114090
Symbol:Egr2
Full Name:early growth response 2
Alias:Krox20
Organism:Rattus norvegicus (Rat)
Chromosome:20
Genetic Location:20p11
Physical Location:21883884-21888176 on NC_005119.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1959    Symbol (Name): EGR2 (early growth response 2 (Krox-20 homolog, Drosophila))
Ortholog Status:The human GeneID 1959 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Egr2
Fold Change:1.43
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Egr2
Fold Change:1.4
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053633.1NP_446085.1NC_005119.2 range: 21883884..21888176, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (8619872)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionTAS (8619872)
GO:0005515protein bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0030528transcription regulator activityMolecular FunctionISS
GO:0045449regulation of transcriptionBiological ProcessISS
GO:0042552myelinationBiological ProcessISS
GO:0032868response to insulin stimulusBiological ProcessIMP (12970165)
GO:0014037Schwann cell differentiationBiological ProcessISS
GO:0007622rhythmic behaviorBiological ProcessISS
GO:0007611learning and/or memoryBiological ProcessIEP (8619872)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0048168regulation of neuronal synaptic plasticityBiological ProcessIEP (8619872)
Other Database Cross Links
NCBI Entrez Gene:114090
RGD:621608
Ensembl:ENSRNOG00000000640
dbSNP:Egr2