ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Egr2

Full Name:

early growth response 2

Alias:

Krox20

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p11

Physical Location:

21883884-21888176 on NC_005119.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1959 Symbol (Name): EGR2 (early growth response 2 (Krox-20 homolog, Drosophila))

Ortholog Status:

The human GeneID 1959 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Egr2
Fold Change:		1.43
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Egr2
Fold Change:		1.4
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053633.1	NP_446085.1	NC_005119.2 range: 21883884..21888176, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (8619872)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	TAS (8619872)
GO:0005515	protein binding	Molecular Function	ISS
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0030528	transcription regulator activity	Molecular Function	ISS
GO:0045449	regulation of transcription	Biological Process	ISS
GO:0042552	myelination	Biological Process	ISS
GO:0032868	response to insulin stimulus	Biological Process	IMP (12970165)
GO:0014037	Schwann cell differentiation	Biological Process	ISS
GO:0007622	rhythmic behavior	Biological Process	ISS
GO:0007611	learning and/or memory	Biological Process	IEP (8619872)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0048168	regulation of neuronal synaptic plasticity	Biological Process	IEP (8619872)