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Gene Information
Gene ID:114246
Full Name:transient receptor potential cation channel, subfamily V, member 6
Organism:Rattus norvegicus (Rat)
Genetic Location:4q22
Physical Location:69331972-69347634 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 55503    Symbol (Name): TRPV6 (transient receptor potential cation channel, subfamily V, member 6)
Ortholog Status:The human GeneID 55503 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Trpv6
Fold Change:1.27
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053686.1NP_446138.1NC_005103.2 range: 69331972..69347634, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005516calmodulin bindingMolecular FunctionISS
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005262calcium channel activityMolecular FunctionISS
GO:0005262calcium channel activityMolecular FunctionIEA
GO:0005227calcium activated cation channel activityMolecular FunctionTAS (12138163)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:114246