ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Chrne

Full Name:

cholinergic receptor, nicotinic, epsilon polypeptide

Alias:

Acre

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 42.0 cM

Physical Location:

70428384-70432695 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1145 Symbol (Name): CHRNE (cholinergic receptor, nicotinic, epsilon)

Ortholog Status:

The human GeneID 1145 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Chrne
Original ID2:		AI326288

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009603.1	NP_033733.1	NC_000077.5 range: 70428384..70432695, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IDA (15883046)
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	IGI (2383398)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0042391	regulation of membrane potential	Biological Process	IGI (2383398)