ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Wnt2

Full Name:

wingless-related MMTV integration site 2

Alias:

Wnt

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q21-q22

Physical Location:

43648917-43689815 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7472 Symbol (Name): WNT2 (wingless-type MMTV integration site family member 2)

Ortholog Status:

The human GeneID 7472 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_575397.2	XP_575397.1	NC_005103.2 range: 43648917..43689815, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008290	F-actin capping protein complex	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0051016	barbed-end actin filament capping	Biological Process	IEA