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Dataset Description
  • Dataset Name: 17451403
  • Species: Rat
  • Method: Microarray and QTL
  • No. of Genes: 35
  • Tissue: Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
  • Phenotype: Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
  • Publication: Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
  • Dataset Summary: A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

    Gene list of this dataset (35 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    312381Ppm1kprotein phosphatase 1K (PP2C domain containing)4q24Ppm1k 
    685879Jazf1JAZF zinc finger 14q24LOC685879 
    297096Snx10sorting nexin 104q24Snx10 
    312301RGD1304879similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71)4q24RGD1304879 
    688848Tsga13testis specific gene A134q22Tsga13 
    29464Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 64q34Slc6a6 
    312251Luc7l2LUC7-like 2 (S. cerevisiae)4q22Luc7l2 
    312248RGD1310722similar to RIKEN cDNA D130059P03 gene4q22RGD1310722 
    362366Fkbp14FK506 binding protein 144q24Fkbp14 
    500069Tsga14testis specific gene A144q22Tsga14 
    362334Tmem140transmembrane protein 1404q22MGC109491 
    116598Pdia4protein disulfide isomerase associated 44q24Pdia4 
    312331Nfe2l3nuclear factor, erythroid derived 2, like 34q24Nfe2l3 
    79220Grid2glutamate receptor, ionotropic, delta 24q24-q31Grid2 
    289883Tmed5transmembrane emp24 protein transport domain containing 514p22Tmed5 
    298694RGD1311019similar to hypothetical protein DKFZp434H20105q36RGD1311019 
    312678LOC312678-4q42LOC312678 
    312381Ppm1kprotein phosphatase 1K (PP2C domain containing)4q24Ppm1k 
    685879Jazf1JAZF zinc finger 14q24LOC685879 
    24192Akr1b1aldo-keto reductase family 1, member B1 (aldose reductase)4q22Akr1b4 
    297096Snx10sorting nexin 104q24Snx10 
    688705Dgkidiacylglycerol kinase, iota4q22LOC500082 
    688848Tsga13testis specific gene A134q22Tsga13 
    312331Nfe2l3nuclear factor, erythroid derived 2, like 34q24Nfe2l3 
    296973Bpgm2,3-bisphosphoglycerate mutase4q22Bpgm 
    286921Akr1b8aldo-keto reductase family 1, member B84q22Akr1b8 
    362368RGD1304876similar to RIKEN cDNA A030007L17; EST AA6731774q24RGD1304876 
    312301RGD1304879similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71)4q24RGD1304879 
    296972Akr1b10aldo-keto reductase family 1, member B10 (aldose reductase)4q22Akr1b10 
    500054LOC500054similar to POT1-like telomere end-binding protein4q22LOC500054 
    79220Grid2glutamate receptor, ionotropic, delta 24q24-q31Grid2 
    29464Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 64q34Slc6a6 
    296966Chchd3coiled-coil-helix-coiled-coil-helix domain containing 34q22Chchd3 
    79215Mtpnmyotrophin4q22Mtpn 
    312225Wdr91WD repeat domain 914q22RGD1306697 
    116598Pdia4protein disulfide isomerase associated 44q24Pdia4 
    25159Gata2GATA binding protein 24q34-q41Gata2 
    114487Wnt2wingless-related MMTV integration site 24q21-q22Wnt2 
    117557Tpm3tropomyosin 3, gamma2q34Tpm3 
    312381Ppm1kprotein phosphatase 1K (PP2C domain containing)4q24Ppm1k 
    296972Akr1b10aldo-keto reductase family 1, member B10 (aldose reductase)4q22Akr1b10 
    297096Snx10sorting nexin 104q24Snx10 
    688705Dgkidiacylglycerol kinase, iota4q22LOC500082 
    685879Jazf1JAZF zinc finger 14q24LOC685879 
    24192Akr1b1aldo-keto reductase family 1, member B1 (aldose reductase)4q22Akr1b4 
    312331Nfe2l3nuclear factor, erythroid derived 2, like 34q24Nfe2l3 
    312225Wdr91WD repeat domain 914q22RGD1306697 
    297066Zfp212Zinc finger protein 2124q24Zfp212 
    312301RGD1304879similar to Zinc finger protein 398 (Zinc finger DNA binding protein p52/p71)4q24RGD1304879 
    81742Pde1cphosphodiesterase 1C4q24Pde1c