| Gene Information |
| Gene ID: | | 81742 |
| Symbol: | | Pde1c |
| Full Name: | | phosphodiesterase 1C |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 4 |
| Genetic Location: | | 4q24 |
| Physical Location: | | 84936641-85448338 on NC_005103.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 5137 Symbol (Name): PDE1C (phosphodiesterase 1C, calmodulin-dependent 70kDa) |
| Ortholog Status: | | The human GeneID 5137 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Pde1c | | Fold Change: | | 1.16 | | P Value: | | 0.0004 | | Tissue: | | Striatum |
| | Dataset Information | | Name: | | 17451403 | | Method: | | Microarray and QTL | | Tissue: | | Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum | | Phenotype: | | Alcohol Preference, alcohol-preferring, alcohol-nonpreferring | | Publication: | | Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed | | Summary: | | A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | Molecular Function | IDA (7568196) | |
| GO:0030552 | cAMP binding | Molecular Function | IDA (7568196) | |
| GO:0007608 | sensory perception of smell | Biological Process | IEP (7568196) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 81742 |
| RGD: | | 68332 |
| Ensembl: | | ENSRNOG00000012337 |
| dbSNP: | | Pde1c |
