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Gene Information
Gene ID:81742
Full Name:phosphodiesterase 1C
Organism:Rattus norvegicus (Rat)
Genetic Location:4q24
Physical Location:84936641-85448338 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5137    Symbol (Name): PDE1C (phosphodiesterase 1C, calmodulin-dependent 70kDa)
Ortholog Status:The human GeneID 5137 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pde1c
Fold Change:1.16
P Value:0.0004
Dataset Information
Method:Microarray and QTL
Tissue:Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031078.1NP_112340.1NC_005103.2 range: 84936641..85448338, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004117calmodulin-dependent cyclic-nucleotide phosphodiesterase activityMolecular FunctionIDA (7568196)
GO:0030552cAMP bindingMolecular FunctionIDA (7568196)
GO:0007608sensory perception of smellBiological ProcessIEP (7568196)
Other Database Cross Links
NCBI Entrez Gene:81742