Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:116598
Full Name:protein disulfide isomerase associated 4
Organism:Rattus norvegicus (Rat)
Genetic Location:4q24
Physical Location:75929397-75948298 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9601    Symbol (Name): PDIA4 (protein disulfide isomerase family A, member 4)
Ortholog Status:The human GeneID 9601 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.4070
Original ID2:ERP70
Fold Change:1.24
P Value:0.00407
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Pdia4
Fold Change:1.24
P Value:0.0017
Gene Information
Original ID1:Pdia4
Fold Change:1.19
P Value:0.0048
Tissue:Frontal cortex
Dataset Information
Method:Microarray and QTL
Tissue:Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053849.1NP_446301.1NC_005103.2 range: 75929397..75948298, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0005788endoplasmic reticulum lumenCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentISS
GO:0016853isomerase activityMolecular FunctionIEA
GO:0003756protein disulfide isomerase activityMolecular FunctionIDA (8477750)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0003756protein disulfide isomerase activityMolecular FunctionIEA
GO:0045454cell redox homeostasisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:116598