ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdia4

Full Name:

protein disulfide isomerase associated 4

Alias:

Erp70|Erp72

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q24

Physical Location:

75929397-75948298 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9601 Symbol (Name): PDIA4 (protein disulfide isomerase family A, member 4)

Ortholog Status:

The human GeneID 9601 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.4070
Original ID2:		ERP70
Fold Change:		1.24
P Value:		0.00407
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053849.1	NP_446301.1	NC_005103.2 range: 75929397..75948298, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0005788	endoplasmic reticulum lumen	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0003756	protein disulfide isomerase activity	Molecular Function	IDA (8477750)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0003756	protein disulfide isomerase activity	Molecular Function	IEA
GO:0045454	cell redox homeostasis	Biological Process	IEA