ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc6a6

Full Name:

solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q34

Physical Location:

125875816-125945794 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6533 Symbol (Name): SLC6A6 (solute carrier family 6 (neurotransmitter transporter, taurine), member 6)

Ortholog Status:

The human GeneID 6533 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017206.1	NP_058902.1	NC_005103.2 range: 125875816..125945794

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IEA
GO:0001761	beta-alanine transmembrane transporter activity	Molecular Function	ISS
GO:0015293	symporter activity	Molecular Function	IEA
GO:0030977	taurine binding	Molecular Function	IDA (1435737)
GO:0005369	taurine:sodium symporter activity	Molecular Function	IEA
GO:0005369	taurine:sodium symporter activity	Molecular Function	IDA (1435737)
GO:0005368	taurine transmembrane transporter activity	Molecular Function	ISS
GO:0015734	taurine transport	Biological Process	IEA
GO:0015734	taurine transport	Biological Process	IMP (1435737)
GO:0015734	taurine transport	Biological Process	ISS
GO:0001762	beta-alanine transport	Biological Process	ISS
GO:0006836	neurotransmitter transport	Biological Process	IEA