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Gene Information
Gene ID:25159
Full Name:GATA binding protein 2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q34-q41
Physical Location:122279752-122288527 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2624    Symbol (Name): GATA2 (GATA binding protein 2)
Ortholog Status:The human GeneID 2624 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gata2
Fold Change:1.15
P Value:0.0057
Tissue:Frontal cortex
Dataset Information
Method:Microarray and QTL
Tissue:Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_033442.1NP_254277.1NC_005103.2 range: 122279752..122288527
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionISS
GO:0030182neuron differentiationBiological ProcessIEA
GO:0030182neuron differentiationBiological ProcessISS
GO:0048469cell maturationBiological ProcessISS
GO:0048469cell maturationBiological ProcessIEA
GO:0045766positive regulation of angiogenesisBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0030154cell differentiationBiological ProcessISS
GO:0021983pituitary gland developmentBiological ProcessISS
GO:0021983pituitary gland developmentBiological ProcessIEA
GO:0001709cell fate determinationBiological ProcessISS
GO:0001892embryonic placenta developmentBiological ProcessISS
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006909phagocytosisBiological ProcessIDA (12933836)
GO:0006909phagocytosisBiological ProcessIEA
GO:0001709cell fate determinationBiological ProcessIEA
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterBiological ProcessISS
GO:0050766positive regulation of phagocytosisBiological ProcessIDA
Other Database Cross Links
NCBI Entrez Gene:25159