ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25159

Symbol:

Gata2

Full Name:

GATA binding protein 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q34-q41

Physical Location:

122279752-122288527 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2624 Symbol (Name): GATA2 (GATA binding protein 2)

Ortholog Status:

The human GeneID 2624 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gata2
Fold Change:		1.15
P Value:		0.0057
Tissue:		Frontal cortex

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_033442.1	NP_254277.1	NC_005103.2 range: 122279752..122288527

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	ISS
GO:0030182	neuron differentiation	Biological Process	IEA
GO:0030182	neuron differentiation	Biological Process	ISS
GO:0048469	cell maturation	Biological Process	ISS
GO:0048469	cell maturation	Biological Process	IEA
GO:0045766	positive regulation of angiogenesis	Biological Process	ISS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	ISS
GO:0021983	pituitary gland development	Biological Process	ISS
GO:0021983	pituitary gland development	Biological Process	IEA
GO:0001709	cell fate determination	Biological Process	ISS
GO:0001892	embryonic placenta development	Biological Process	ISS
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006909	phagocytosis	Biological Process	IDA (12933836)
GO:0006909	phagocytosis	Biological Process	IEA
GO:0001709	cell fate determination	Biological Process	IEA
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0050766	positive regulation of phagocytosis	Biological Process	IDA