| Gene Information |
| Gene ID: | | 362334 |
| Symbol: | | Tmem140 |
| Full Name: | | transmembrane protein 140 |
| Alias: | | MGC109491 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 4 |
| Genetic Location: | | 4q22 |
| Physical Location: | | 62248801-62259800 on NC_005103.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 55281 Symbol (Name): TMEM140 (transmembrane protein 140) |
| Ortholog Status: | | The human GeneID 55281 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | MGC109491 | | Fold Change: | | 1.32 | | P Value: | | 0.0015 | | Tissue: | | Amygdala |
| | Gene Information | | Original ID1: | | MGC109491 | | Fold Change: | | 1.14 | | P Value: | | 0.0013 | | Tissue: | | Hippocampus |
| | Dataset Information | | Name: | | 17451403 | | Method: | | Microarray and QTL | | Tissue: | | Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum | | Phenotype: | | Alcohol Preference, alcohol-preferring, alcohol-nonpreferring | | Publication: | | Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed | | Summary: | | A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 362334 |
| RGD: | | 1549759 |
| Ensembl: | | ENSRNOG00000026965 |
| dbSNP: | | Tmem140 |
