ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Akr1b8

Full Name:

aldo-keto reductase family 1, member B8

Alias:

MGC91427

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q22

Physical Location:

61714281-61726855 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57016 Symbol (Name): AKR1B10 (aldo-keto reductase family 1, member B10 (aldose reductase))

Ortholog Status:

The human GeneID 57016 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_173136.1	NP_775159.1	NC_005103.2 range: 61714281..61726855

Gene Ontology (GO) Annotation