ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dgki

Full Name:

diacylglycerol kinase, iota

Alias:

rDGKi-3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q22

Physical Location:

64207191-64663626 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9162 Symbol (Name): DGKI (diacylglycerol kinase, iota)

Ortholog Status:

The human GeneID 9162 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Information

Original ID1:		Dgki
Fold Change:		-1.19
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (15024004)
GO:0004143	diacylglycerol kinase activity	Molecular Function	IDA (15024004)
GO:0004143	diacylglycerol kinase activity	Molecular Function	IEA
GO:0007205	activation of protein kinase C activity	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA