ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Akr1b1

Full Name:

aldo-keto reductase family 1, member B1 (aldose reductase)

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q22

Physical Location:

61645437-61659529 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 231 Symbol (Name): AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase))

Ortholog Status:

The human GeneID 231 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.2917
Original ID2:		Aldr1
Fold Change:		1.18
P Value:		0.00019
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012498.1	NP_036630.1	NC_005103.2 range: 61645437..61659529, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (16332428)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004032	aldehyde reductase activity	Molecular Function	IDA (2114645)
GO:0004032	aldehyde reductase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0046427	positive regulation of JAK-STAT cascade	Biological Process	IMP (15746188)
GO:0031098	stress-activated protein kinase signaling pathway	Biological Process	IMP (16669970)
GO:0010033	response to organic substance	Biological Process	IDA (16567803)
GO:0006061	sorbitol biosynthetic process	Biological Process	IMP (6690344)
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process	IMP (16648138)