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Gene Information
Gene ID:79220
Full Name:glutamate receptor, ionotropic, delta 2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q24-q31
Physical Location:92642426-94054756 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2895    Symbol (Name): GRID2 (glutamate receptor, ionotropic, delta 2)
Ortholog Status:The human GeneID 2895 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Grid2
Fold Change:-1.21
P Value:0.0044
Gene Information
Original ID1:Grid2
Fold Change:-1.14
P Value:0.0022
Tissue:Frontal cortex
Dataset Information
Method:Microarray and QTL
Tissue:Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024379.1NP_077355.1NC_005103.2 range: 92642426..94054756
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0019717synaptosomeCellular ComponentISS
GO:0019717synaptosomeCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0035249synaptic transmission, glutamatergicBiological ProcessISS
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessISS
GO:0060134prepulse inhibitionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:79220