ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Grid2

Full Name:

glutamate receptor, ionotropic, delta 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q24-q31

Physical Location:

92642426-94054756 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2895 Symbol (Name): GRID2 (glutamate receptor, ionotropic, delta 2)

Ortholog Status:

The human GeneID 2895 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024379.1	NP_077355.1	NC_005103.2 range: 92642426..94054756

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0019717	synaptosome	Cellular Component	ISS
GO:0019717	synaptosome	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004970	ionotropic glutamate receptor activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0035249	synaptic transmission, glutamatergic	Biological Process	ISS
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	ISS
GO:0060134	prepulse inhibition	Biological Process	ISS