ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mtpn

Full Name:

myotrophin

Alias:

Gcdp|MGC108675

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q22

Physical Location:

62895253-62924181 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 136319 Symbol (Name): MTPN (myotrophin)

Ortholog Status:

The human GeneID 136319 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17451403
Method:		Microarray and QTL
Tissue:		Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:		Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:		Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:		A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024374.4	NP_077350.1	NC_005103.2 range: 62895253..62924181, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IDA (12419325\|17041682)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0030424	axon	Cellular Component	IDA (12419325)
GO:0005515	protein binding	Molecular Function	NAS
GO:0043403	skeletal muscle regeneration	Biological Process	IEP (12467730)
GO:0030182	neuron differentiation	Biological Process	NAS
GO:0021707	cerebellar granule cell differentiation	Biological Process	IEP (8144589)
GO:0006584	catecholamine metabolic process	Biological Process	IEP (12051753)
GO:0051146	striated muscle cell differentiation	Biological Process	IEP (12467730)