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Gene Information
Gene ID:79215
Full Name:myotrophin
Organism:Rattus norvegicus (Rat)
Genetic Location:4q22
Physical Location:62895253-62924181 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 136319    Symbol (Name): MTPN (myotrophin)
Ortholog Status:The human GeneID 136319 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mtpn
Fold Change:-1.14
P Value:0.0039
Tissue:Frontal cortex
Dataset Information
Method:Microarray and QTL
Tissue:Nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum
Phenotype:Alcohol Preference, alcohol-preferring, alcohol-nonpreferring
Publication:Carr et al. Alcohol Clin Exp Res. (2007) Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. PubMed
Summary:A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP (inbred alcohol-preferring) and iNP (inbred alcohol-nonpreferring) rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. Analyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024374.4NP_077350.1NC_005103.2 range: 62895253..62924181, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005622intracellularCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIDA (12419325|17041682)
GO:0005737cytoplasmCellular ComponentIEA
GO:0030424axonCellular ComponentIDA (12419325)
GO:0005515protein bindingMolecular FunctionNAS
GO:0043403skeletal muscle regenerationBiological ProcessIEP (12467730)
GO:0030182neuron differentiationBiological ProcessNAS
GO:0021707cerebellar granule cell differentiationBiological ProcessIEP (8144589)
GO:0006584catecholamine metabolic processBiological ProcessIEP (12051753)
GO:0051146striated muscle cell differentiationBiological ProcessIEP (12467730)
Other Database Cross Links
NCBI Entrez Gene:79215