ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

114505

Symbol:

Klf4

Full Name:

Kruppel-like factor 4 (gut)

Alias:

GKLF|MGC93286

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q24

Physical Location:

73446927-73451285 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9314 Symbol (Name): KLF4 (Kruppel-like factor 4 (gut))

Ortholog Status:

The human GeneID 9314 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Klf4
Fold Change:		1.38
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053713.1	NP_446165.1	NC_005104.2 range: 73446927..73451285, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IDA (15632413)
GO:0005667	transcription factor complex	Cellular Component	IDA (15632413)
GO:0005634	nucleus	Cellular Component	IDA (15632413)
GO:0005622	intracellular	Cellular Component	IEA
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	ISS
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (12034813\|15632413\|17659301)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (12034813)
GO:0003700	transcription factor activity	Molecular Function	IDA (12034813)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IDA (17659301)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12034813\|17659301)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0048662	negative regulation of smooth muscle cell proliferation	Biological Process	IDA (17659301)
GO:0031077	post-embryonic camera-type eye development	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	ISS
GO:0019827	stem cell maintenance	Biological Process	ISS
GO:0009913	epidermal cell differentiation	Biological Process	ISS
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS
GO:0048730	epidermis morphogenesis	Biological Process	ISS