ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Zyx

Full Name:

zyxin

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q23

Physical Location:

70119040-70128080 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7791 Symbol (Name): ZYX (zyxin)

Ortholog Status:

The human GeneID 7791 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.87247
Original ID2:		Zyx
Fold Change:		2.16
P Value:		0
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_216124.4	XP_216124.3	NC_005103.2 range: 70119040..70128080

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005913	cell-cell adherens junction	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0050727	regulation of inflammatory response	Biological Process	IEP (11748220)