ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Actc1

Full Name:

actin, alpha, cardiac

Alias:

Actc-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 E4|2 64.0 cM

Physical Location:

113873024-113878546 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 70 Symbol (Name): ACTC1 (actin, alpha, cardiac muscle 1)

Ortholog Status:

The human GeneID 70 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Actc1
Original ID2:		M15501

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009608.3	NP_033738.1	NC_000068.6 range: 113873024..113878546, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0015629	actin cytoskeleton	Cellular Component	RCA (12466851)
GO:0031674	I band	Cellular Component	IDA (16481394)
GO:0005884	actin filament	Cellular Component	RCA (12466851)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	RCA (12466851)
GO:0008307	structural constituent of muscle	Molecular Function	RCA (12466851)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0055003	cardiac myofibril assembly	Biological Process	IMP (9114002)
GO:0031032	actomyosin structure organization and biogenesis	Biological Process	IMP (14605248)
GO:0030240	muscle thin filament assembly	Biological Process	IMP (9114002)
GO:0008016	regulation of heart contraction	Biological Process	RCA (12466851)
GO:0007517	muscle development	Biological Process	RCA (12466851)
GO:0006936	muscle contraction	Biological Process	RCA (12466851)
GO:0006915	apoptosis	Biological Process	IMP (14605248)
GO:0055008	cardiac muscle morphogensis	Biological Process	IMP (14605248)