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Gene Information
Gene ID:114765
Symbol:Wbp4
Full Name:WW domain binding protein 4
Alias:Fbp21
Organism:Rattus norvegicus (Rat)
Chromosome:15
Genetic Location:15q12
Physical Location:61517403-61543452 on NC_005114.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 11193    Symbol (Name): WBP4 (WW domain binding protein 4 (formin binding protein 21))
Ortholog Status:The human GeneID 11193 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Wbp4
Fold Change:-1.12
P Value:0.004
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053766.1NP_446218.1NC_005114.2 range: 61517403..61543452, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005681spliceosomeCellular ComponentISS
GO:0016607nuclear speckCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006397mRNA processingBiological ProcessIEA
GO:0008380RNA splicingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:114765
RGD:620033
Ensembl:ENSRNOG00000011678
dbSNP:Wbp4