ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Acvrl1

Full Name:

activin A receptor, type II-like 1

Alias:

AI115505|AI427544|Acvrlk1|Alk-1|Alk1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F3

Physical Location:

100958967-100975766 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 94 Symbol (Name): ACVRL1 (activin A receptor type II-like 1)

Ortholog Status:

The human GeneID 94 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L48015
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Gene Information

Original ID1:		Z31664
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009612.2	NP_033742.2	NC_000081.5 range: 100958967..100975766

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	ISO
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016361	activin receptor activity, type I	Molecular Function	ISO
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14580334)
GO:0005024	transforming growth factor beta receptor activity	Molecular Function	ISO
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IDA (14580334)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0001701	in utero embryonic development	Biological Process	IMP (17911384)
GO:0001525	angiogenesis	Biological Process	IMP (10716993\|11062473)
GO:0048514	blood vessel morphogenesis	Biological Process	IMP (17530030\|17911384)