ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Afg3l1

Full Name:

AFG3(ATPase family gene 3)-like 1 (yeast)

Alias:

1700047G05Rik|3110061K15Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 E1-E2

Physical Location:

126001802-126027815 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 172 Symbol (Name): AFG3L1 (AFG3 ATPase family gene 3-like 1 (S. cerevisiae))

Ortholog Status:

The human GeneID 172 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA797556
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_054070.2	NP_473411.2	NC_000074.5 range: 126001802..126027815

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (11549317\|14651853)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004222	metalloendopeptidase activity	Molecular Function	ISS (11549317)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0006508	proteolysis	Biological Process	IEA
GO:0030163	protein catabolic process	Biological Process	IEA