ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adcyap1

Full Name:

adenylate cyclase activating polypeptide 1

Alias:

PACAP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 E5

Physical Location:

93598761-93604830 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 116 Symbol (Name): ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary))

Ortholog Status:

The human GeneID 116 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adcyap1
Original ID2:		AB010149

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009625.2	NP_033755.1	NC_000083.5 range: 93598761..93604830

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005057	receptor signaling protein activity	Molecular Function	IDA (12473665)
GO:0005057	receptor signaling protein activity	Molecular Function	TAS (9729410)
GO:0005179	hormone activity	Molecular Function	IEA
GO:0005184	neuropeptide hormone activity	Molecular Function	TAS (9729410)
GO:0007190	activation of adenylate cyclase activity	Biological Process	TAS (9729410)
GO:0007218	neuropeptide signaling pathway	Biological Process	TAS (9729410)
GO:0045786	negative regulation of cell cycle	Biological Process	IDA (12417650)