ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adsl

Full Name:

adenylosuccinate lyase

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E1|15 46.0 cM

Physical Location:

80778948-80799802 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 158 Symbol (Name): ADSL (adenylosuccinate lyase)

Ortholog Status:

The human GeneID 158 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adsl
Original ID2:		AA606587

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009634.5	NP_033764.2	NC_000081.5 range: 80778948..80799802

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004018	adenylosuccinate lyase activity	Molecular Function	ISS (8995283)
GO:0016829	lyase activity	Molecular Function	IEA
GO:0006164	purine nucleotide biosynthetic process	Biological Process	IEA
GO:0009152	purine ribonucleotide biosynthetic process	Biological Process	IEA