ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adss

Full Name:

adenylosuccinate synthetase, non muscle

Alias:

AI314886|AS|Adss2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H4

Physical Location:

179693308-179726639 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 159 Symbol (Name): ADSS (adenylosuccinate synthase)

Ortholog Status:

The human GeneID 159 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adss2
Original ID2:		L24554

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007422.3	NP_031448.2	NC_000067.5 range: 179693308..179726639, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004019	adenylosuccinate synthase activity	Molecular Function	IDA (8308018\|12482871)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006164	purine nucleotide biosynthetic process	Biological Process	IDA (12482871)
GO:0006167	AMP biosynthetic process	Biological Process	IDA (8308018)