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Gene Information
Gene ID:116470
Symbol:Stx1a
Full Name:syntaxin 1A (brain)
Organism:Rattus norvegicus (Rat)
Chromosome:12
Genetic Location:12q12
Physical Location:22737111-22765063 on NC_005111.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6804    Symbol (Name): STX1A (syntaxin 1A (brain))
Ortholog Status:The human GeneID 6804 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:116470
Fold Change:1.508
P Value:0.013
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Name:15846778
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053788.2NP_446240.2NC_005111.2 range: 22737111..22765063, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentNAS
GO:0005886plasma membraneCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIDA (11331586)
GO:0030141secretory granuleCellular ComponentIDA
GO:0030672synaptic vesicle membraneCellular ComponentISS
GO:0042641actomyosinCellular ComponentIDA (16030255)
GO:0030674protein binding, bridgingMolecular FunctionIPI (16030255)
GO:0046982protein heterodimerization activityMolecular FunctionIDA (16030255)
GO:0048306calcium-dependent protein bindingMolecular FunctionIPI (16030255)
GO:0017022myosin bindingMolecular FunctionIPI (16030255)
GO:0019855calcium channel inhibitor activityMolecular FunctionIEA
GO:0019855calcium channel inhibitor activityMolecular FunctionISS
GO:0043008ATP-dependent protein bindingMolecular FunctionIPI (16030255)
GO:0032028myosin head/neck bindingMolecular FunctionIPI (16030255)
GO:0000149SNARE bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0000149SNARE bindingMolecular FunctionIPI (16030255)
GO:0000149SNARE bindingMolecular FunctionISS
GO:0005484SNAP receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (1334074)
GO:0005515protein bindingMolecular FunctionIPI (15339904)
GO:0045921positive regulation of exocytosisBiological ProcessIDA (11331586)
GO:0001956positive regulation of neurotransmitter secretionBiological ProcessIMP (12183029)
GO:0009629response to gravityBiological ProcessIDA (15076716)
GO:0006836neurotransmitter transportBiological ProcessIEA
GO:0006836neurotransmitter transportBiological ProcessTAS (11846792)
GO:0017157regulation of exocytosisBiological ProcessIMP (16030255)
GO:0017156calcium ion-dependent exocytosisBiological ProcessISS
GO:0017156calcium ion-dependent exocytosisBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessIEA
GO:0016081synaptic vesicle docking during exocytosisBiological ProcessIEP
Other Database Cross Links
NCBI Entrez Gene:116470
RGD:69430
Ensembl:ENSRNOG00000029165
dbSNP:Stx1a