ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Akp3

Full Name:

alkaline phosphatase 3, intestine, not Mn requiring

Alias:

Akp-3|IAP|dIAP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 D|1 51.7 cM

Physical Location:

89021582-89024486 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Akp3
Original ID2:		M61705

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007432.2	NP_031458.2	NC_000067.5 range: 89021582..89024486

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0031225	anchored to membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004035	alkaline phosphatase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA