ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

11651

Symbol:

Akt1

Full Name:

thymoma viral proto-oncogene 1

Alias:

Akt|PKB|PKB/Akt|PKBalpha

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 F1-F2|12 57.0 cM

Physical Location:

113892031-113912400 on NC_000078.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 207 Symbol (Name): AKT1 (v-akt murine thymoma viral oncogene homolog 1)

Ortholog Status:

The human GeneID 207 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mm.6645
Original ID2:		H3020C06
Fold Change:		-0.6176

Dataset Information

Name:		15668661
Method:		Microarray
Tissue:		Fetal brain
Phenotype:		Ethanol response
Publication:		Hard et al. J Lab Clin Med. (2005) Gene-expression analysis after alcohol exposure in the developing mouse. PubMed
Summary:		Exposure to alcohol in the embryonic mouse can lead to structural and neurophysiologic changes. Here we investigate ethanol-induced alterations in gene expression in the fetal brain. Using complementary-DNA microarrays, we identified 25 genes that were down-regulated by prenatal ethanol exposure on days 7 and 9 of gestation. None were found to be up-regulated.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009652.2	NP_033782.1	NC_000078.5 range: 113892031..113912400, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005819	spindle	Cellular Component	IDA (15509711)
GO:0030027	lamellipodium	Cellular Component	IDA (12944902)
GO:0005886	plasma membrane	Cellular Component	ISS (14749367)
GO:0005829	cytosol	Cellular Component	EXP (10454575)
GO:0005737	cytoplasm	Cellular Component	IDA (12124386)
GO:0005634	nucleus	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	ISS (14749367)
GO:0005515	protein binding	Molecular Function	IPI (12791994\|15753085\|16357133)
GO:0004672	protein kinase activity	Molecular Function	IDA (14730361\|15010863\|15192701)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0005351	sugar:hydrogen symporter activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016567	protein ubiquitination	Biological Process	IDA (12145204)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (16513828)
GO:0015758	glucose transport	Biological Process	IMP (9415393)
GO:0030030	cell projection organization and biogenesis	Biological Process	ISS (16286931)
GO:0030163	protein catabolic process	Biological Process	IDA (12145204)
GO:0032094	response to food	Biological Process	IDA (16513828)
GO:0040018	positive regulation of multicellular organism growth	Biological Process	IMP (12783884)
GO:0042640	anagen	Biological Process	IMP (15713628)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (11282895)
GO:0043491	protein kinase B signaling cascade	Biological Process	IGI (15249583)
GO:0045792	negative regulation of cell size	Biological Process	ISS (16286931)
GO:0045884	regulation of survival gene product expression	Biological Process	IDA (14730361)
GO:0009725	response to hormone stimulus	Biological Process	IDA (16357133)
GO:0008643	carbohydrate transport	Biological Process	IEA
GO:0008637	apoptotic mitochondrial changes	Biological Process	IDA (12869584)
GO:0001890	placenta development	Biological Process	IMP (12783884)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0005977	glycogen metabolic process	Biological Process	IMP (12783884)
GO:0005978	glycogen biosynthetic process	Biological Process	IEA
GO:0006006	glucose metabolic process	Biological Process	IEA
GO:0006417	regulation of translation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12145204\|14730361\|15192701)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS (14749367)
GO:0006810	transport	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IDA (12124386)
GO:0006924	activated T cell apoptosis	Biological Process	ISS (14749367)
GO:0006954	inflammatory response	Biological Process	IDA (14730361)
GO:0007242	intracellular signaling cascade	Biological Process	ISS (14749367)
GO:0007281	germ cell development	Biological Process	IDA (12140361)
GO:0008286	insulin receptor signaling pathway	Biological Process	IMP (9415393\|11282895)
GO:0001568	blood vessel development	Biological Process	IMP (12783884)